Key result
Adding linezolid to escitalopram linked to near-fatal serotonin syndrome in a sepsis patient.
Why the study?
Concomitant therapy with linezolid and serotonergic agents may induce serotonin syndrome, but detailed clinical reports of near-fatal interactions are limited.
Case Report (n=1)
Highlights the risk of near-fatal serotonin syndrome when linezolid is co-administered with serotonergic agents like escitalopram.
Supports vigilance for serotonin syndrome with linezolid plus SSRIs; case reports leave open incidence and risk stratification.
Linezolid is a synthetic antimicrobial agent of the oxazolidinone class with weak, nonspecific inhibitor of monoamine oxidase enzymes. Concomitant therapy with an adrenergic or serotonergic agent or consuming tyramine (>100 mg/day) may induce serotonin syndrome (SS). We present a case report of near-fatal adverse interaction between linezolid and escitalopram inducing SS in a 65-year-old woman with sepsis, under empirical antibiotic treatment. This report also summarizes the current relevant literature as identified via PubMed, EMBASE, and PsycINFO, supplemented with a manual search of cross references.
No takes yet. Share an insight, caveat, or question.
Kulkarni et al. (2013) conducted a case report in Sepsis and Serotonin Syndrome (n=1). Concomitant linezolid and escitalopram was evaluated on Serotonin syndrome. Concomitant use of linezolid and escitalopram induced a near-fatal serotonin syndrome in a 65-year-old woman being treated for sepsis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: