Key result
Concomitant use of linezolid and serotonergic antidepressants resulted in symptoms highly suggestive of serotonin syndrome in 1.8% (1 of 53) of patients.
Why the study?
Does the combination of linezolid and serotonergic antidepressants cause serotonin syndrome?
Population
53 patients receiving a combination of linezolid and serotonergic antidepressants, along with two specific…
Design
Cohort
Authors
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May warrant vigilance with linezolid plus serotonergic antidepressants; leaves open precise incidence in larger cohorts.
Observational (n=53)
No
Does the combination of linezolid and serotonergic antidepressants cause serotonin syndrome?
The combination of linezolid and serotonergic antidepressants carries a rare but serious risk of serotonin syndrome.
Lorenz et al. (2008) conducted an observational in Patients receiving linezolid and serotonergic antidepressants (n=53). Combination of linezolid and serotonergic antidepressants was evaluated on Symptoms highly suggestive of serotonin syndrome. Concomitant use of linezolid and serotonergic antidepressants resulted in symptoms highly suggestive of serotonin syndrome in 1.8% (1 of 53) of patients.
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