What question did this study set out to answer?

This research aims to determine the feasibility of reversing advanced atherosclerosis in humans and animals.

August 1, 1976Annals of the New York Academy of Sciences

Studies of Regression of Advanced Atherosclerosis in Experimental Animals and Man*

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Why the study?

Does a low-fat low-cholesterol diet improve regression of advanced atherosclerosis in humans and experimental animals?

Population

Humans and experimental animals (rhesus monkeys) with advanced atherosclerosis

Design

Review

Authors

RWRobert W. WisslerGeneral / Preventive / Lipids DVDragoslava VesselinovitchUniversity of Chicago

Discussion

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Implication

May support intensive cholesterol lowering for regression; leaves open optimal modern strategies and trial confirmation.

Key Points

This research aims to determine the feasibility of reversing advanced atherosclerosis in humans and animals.
Reduction of serum cholesterol concentrations in subjects consuming low-fat, low-cholesterol diets.
Observation of lipid disappearance from plaques and changes in fibrous tissue structure.
Serum cholesterol levels around 150 mg% were found to significantly promote plaque regression.
Lipid removal from plaques accompanied remodeling, akin to wound healing.
Interruption of atherosclerosis progression was identified as a more achievable goal.

Structured PICO

Does a low-fat low-cholesterol diet improve regression of advanced atherosclerosis in humans and experimental animals?

Population

Humans and experimental animals (rhesus monkeys) with advanced atherosclerosis

Intervention

Low-fat low-cholesterol diet to reduce serum cholesterol to ~150 mg%

Outcome

Regression of advanced atherosclerosissurrogate

This review highlights that substantial regression of advanced atherosclerosis is possible by aggressively lowering serum cholesterol.

Cite This Study

Wissler et al. (1976) studied this question.

synapsesocial.com/papers/6a1fa166781caea79af85bc5 https://doi.org/10.1111/j.1749-6632.1976.tb43368.x

Topics

Coronary artery disease

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Studies of Regression of Advanced Atherosclerosis in Experimental Animals and Man*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Studies of Regression of Advanced Atherosclerosis in Experimental Animals and Man*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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