Key result
Intensive risk factor reduction is linked to ~0.05 mm increase in coronary arterial diameter.
Why the study?
The impact of intensive risk factor reduction on coronary artery morphology in patients with mildly elevated LDL cholesterol was unclear.
Population
14 patients with angiographically proven coronary atherosclerosis and mildly elevated LDL
Comparison
Intensive risk factor reduction versus baseline status
Design
Cohort study with quantitative angiography before and after intervention
Follow-up
2 years
Authors
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May support angiographic regression via intensive modification in mild LDL elevation; leaves open need for larger randomized trials.
Cohort (n=14)
No
Mean Difference: 0.05
Absolute Event Rate: 2.81% vs 2.74%
p-value: p=0.01
Schaefer et al. (1997) conducted a cohort in Coronary atherosclerosis with mildly elevated LDL (n=14). Intensive risk factor reduction (pharmacologic and nonpharmacologic interventions) vs. Baseline was evaluated on Changes in coronary artery diameter (MD +0.05 mm, p=0.01). Intensive risk factor reduction over 2 years in patients with mild LDL elevation significantly increased average coronary arterial diameter by 0.05 mm (p=0.01), with regression of severe lesions.
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