November 18, 2003Circulation
Relation Between Progression and Regression of Atherosclerotic Left Main Coronary Artery Disease and Serum Cholesterol Levels as Assessed With Serial Long-Term (≥12 Months) Follow-Up Intravascular Ultrasound
Why the study?
Do serum LDL and HDL cholesterol levels correlate with the progression or regression of mild atherosclerotic plaques in the left main coronary artery?
Population
60 left main coronary arteries with mild atherosclerotic plaques undergoing serial intravascular ultrasound…
Design
Cohort
Follow-up
18.3+/-9.4 months
Authors
Discussion
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Implication
Supports LDL <75 mg/dL to limit mild left main plaque progression; leaves open outcome benefits in randomized trials.
Structured PICO
Do serum LDL and HDL cholesterol levels correlate with the progression or regression of mild atherosclerotic plaques in the left main coronary artery?
P
Population
60 left main coronary arteries with mild atherosclerotic plaques undergoing serial intravascular ultrasound (IVUS) studies
I
Intervention
Serum LDL and HDL cholesterol levels (observational exposure)
O
Outcome
Annual changes in plaque plus media (P&M) cross-sectional area (CSA) and lumen CSA assessed by serial IVUSsurrogate
An LDL cholesterol level of 75 mg/dL or lower is associated with a halt in the progression of mild atherosclerotic plaques in the left main coronary artery, providing direct imaging evidence for aggressive lipid-lowering targets.
Cite This Study
Birgelen et al. (2003) studied this question.