Key result
Low HDL-C linked to ~71% higher frequency of attenuated plaque vs high HDL-C in CAD.
Why the study?
Is low HDL-C associated with specific coronary lesion characteristics on IVUS in patients with coronary artery disease?
Observational (n=120)
Is low HDL-C associated with specific coronary lesion characteristics on IVUS in patients with coronary artery disease?
Absolute Event Rate: 48.3% vs 28.3%
p-value: p=0.02
Low HDL-C levels are independently associated with a higher incidence of attenuated plaques on IVUS in patients with coronary artery disease.
Low HDL-C may mark higher-risk plaques on IVUS in CAD; leaves open causal and therapeutic implications.
OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease. BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events. METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40 mg/dL, n = 60) and a high HDL-C group (≥40 mg/dL, n = 60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics. RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r = 0.03, P = 0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P = 0.02) and a greater percentage of attenuated plaque was found in this group (32.5 ± 21.3% vs. 21.0 ± 11.0%, P = 0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30 mg/dL, 41.9% in group with 30-39 mg/dL, 36.4% in group with 40-59 mg/dL, and 6.3% in group with ≥60 mg/dL; P = 0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions. CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.
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Kitabata et al. (2014) conducted an observational in Coronary artery disease (n=120). Low HDL-C (<40 mg/dL) vs. High HDL-C (≥40 mg/dL) was evaluated on Frequency of attenuated plaque (p=0.02). Low HDL-C (<40 mg/dL) was associated with a significantly higher frequency of attenuated plaque compared to high HDL-C (48.3% vs. 28.3%, P=0.02) in patients with coronary artery disease.