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June 1, 1996Journal of the American College of CardiologyOpen Access

Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: Correlation with high density lipoproteins

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Why the study?

Does intravascular ultrasound detect more angiographically silent atherosclerosis than angiography in asymptomatic patients with familial hypercholesterolemia or familial combined hyperlipidemia?

Population

48 nonsmoking, asymptomatic patients with heterozygous familial hypercholesterolemia or familial combined…

Comparison

Intravascular ultrasound imaging of the left… vs Angiography

Design

Cross-sectional

Authors

DHDirk HausmannMedizinische Hochschule HannoverJJJay A. JohnsonWestern UniversityKSKrishnankutty SudhirInterventional / Structural Cardiology

Discussion

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Implication

IVUS may detect more silent plaque than angiography in asymptomatic FH; hypothesis-generating for risk stratification.

Structured PICO

Does intravascular ultrasound detect more angiographically silent atherosclerosis than angiography in asymptomatic patients with familial hypercholesterolemia or familial combined hyperlipidemia?

P
Population
48 nonsmoking, asymptomatic patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia
I
Intervention
Intravascular ultrasound imaging of the left anterior descending coronary, left main coronary and common iliac arteries
C
Comparator
Angiography
O
Outcome
Plaque burden (mean and maximal intimal index, and percent of vessel surface covered by plaque)surrogate

Intravascular ultrasound reveals extensive, angiographically silent coronary plaque in asymptomatic patients with familial hypercholesterolemia, with HDL cholesterol levels being a strong predictor of plaque burden.

Cite This Study

Hausmann et al. (1996) studied this question.

synapsesocial.com/papers/6a20815cdf4cd797f4f42362https://doi.org/10.1016/0735-1097(96)00048-4

Topics

Coronary artery diseaseCoronary CT angiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship of Atherosclerosis in Young Men to Serum Lipoprotein Cholesterol Concentrations and Smoking1990 · 405 citations
  2. 2Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities.1992 · 126 citations
  3. 3SINKING PRE-BETA LIPOPROTEIN AND CORONARY HEART DISEASE IN JAPANESE-AMERICAN MEN IN HAWAII1978 · 48 citations
  4. 4Impact of compensatory enlargement of atherosclerotic coronary arteries on angiographic assessment of coronary artery disease.1989 · 165 citations
  5. 5Delineation of the Extent of Coronary Atherosclerosis by High-Frequency Epicardial Echocardiography1987 · 217 citations