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July 1, 1990Echocardiography

The predictive accuracy of evaluating plaque composition in the validation set of 28 ultrasound imaging sites was 96%.

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Why the study?

Does intravascular ultrasound accurately differentiate atherosclerotic plaque morphology subtypes compared to histology in excised coronary segments?

Population

60 coronary segments excised from 33 coronary arteries obtained from 17 patients at necropsy

Comparison

Intravascular ultrasound using a 25-MHz… vs Histologic transverse sections and plane film…

Design

Preclinical

Authors

ABAntonio L. BartorelliBPBenjamin N. PotkinYAYaron Almagor

Discussion

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Overview

Supports ex vivo IVUS plaque assessment; leaves open in vivo human validation before clinical use.

Structured PICO

Does intravascular ultrasound accurately differentiate atherosclerotic plaque morphology subtypes compared to histology in excised coronary segments?

P
Population
60 coronary segments excised from 33 coronary arteries obtained from 17 patients at necropsy
I
Intervention
Intravascular ultrasound using a 25-MHz transducer mounted on the distal end of a rigid probe rotated manually inside the lumen artery
C
Comparator
Histologic transverse sections and plane film radiography
O
Outcome
Predictive accuracy of evaluating plaque composition (fibrous, lipid, calcific) with intravascular ultrasound compared to histologysurrogate

Intravascular ultrasound can accurately assess the anatomical structure and composition of atherosclerotic lesions ex vivo, demonstrating high predictive accuracy compared to histology.

Cite This Study

Bartorelli et al. (1990) studied this question.

synapsesocial.com/papers/6a952b230da585886d769e32https://doi.org/10.1111/j.1540-8175.1990.tb00379.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary artery imaging with intravascular high-frequency ultrasound.1990 · 601 citations
  2. 2Coronary Plaque Classification With Intravascular Ultrasound Radiofrequency Data Analysis2002 · 1,129 citations
  3. 3Intravascular Ultrasound Imaging of Human Cerebral Arteries1996 · 12 citations
  4. 4Characterization of Plaque Components With Intravascular Ultrasound Elastography in Human Femoral and Coronary Arteries In Vitro2000 · 384 citations
  5. 5Assessment of normal and atherosclerotic arterial wall thickness with an intravascular ultrasound imaging catheter1990 · 209 citations