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May 1, 1990CirculationOpen Access

Coronary artery imaging with intravascular high-frequency ultrasound.

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Authors

BPBenjamin N. PotkinRutgers, The State University of New Jersey ABA. BartorelliInterventional / Structural Cardiology JGJames GessertUnited Microelectronics (United States)

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Implication

Randomized trial assesses the reliability of intravascular ultrasound for accurate imaging of atherosclerotic plaques, suggesting clinical utility in diagnosis and therapy guidance.

Key Points

The aim is to evaluate the reliability of catheter-based intravascular ultrasound for imaging coronary arteries affected by atherosclerosis.
Used a miniaturized prototype ultrasound system with a 1-mm transducer at 25 MHz to image human coronary arteries from necropsy specimens.
Compared ultrasound images of 54 atherosclerotic sites to formalin-fixed and fresh histological sections using digital video planimetry.
Correlations were established for various measurements including cross-sectional area and wall thickness across multiple angles.
Ultrasound and histological measurements correlated significantly for coronary artery cross-sectional area (r = 0.94, p < 0.0001).
Residual lumen cross-sectional area had a correlation of r = 0.85, and percent cross-sectional area had r = 0.84, all with p < 0.0001.
Ultrasound accurately predicted histological plaque composition in 96% of cases.

Cite This Study

Potkin et al. (1990) studied this question.

synapsesocial.com/papers/69ffcca8d1d8b50f8e9a12cd https://doi.org/10.1161/01.cir.81.5.1575

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Plaque Characterization of Atherosclerotic Coronary Arteries by Intravascular Ultrasound1990 · 51 citations
2Assessment of normal and atherosclerotic arterial wall thickness with an intravascular ultrasound imaging catheter1990 · 209 citations
3Percutaneous Intracoronary Ultrasound Imaging: Initial Applications in Patients1990 · 43 citations
4Intravascular Ultrasound Imaging of Human Cerebral Arteries1996 · 12 citations
5Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease.1991 · 668 citations