Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease.
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Discussion
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Implication
Randomized trial assesses lumen size and wall characteristics in normal subjects and CAD patients, suggesting its safety and feasibility.
Key Points
- This research aims to evaluate the effectiveness and safety of intravascular ultrasound in measuring coronary lumen size and wall morphology in patients with and without coronary artery disease.
- Used a multielement 5.5F, 20-MHz ultrasound catheter to assess normal subjects (N=8) and patients with CAD (N=43).
- Evaluated correlation between minimum luminal diameter from angiography and ultrasound across different vessel geometries.
- Examined wall morphology and stenosis severity using intravascular ultrasound.
- In normal subjects, correlation between angiographic and ultrasonic minimum diameter is high (r = 0.92).
- In CAD patients, a concentric cross-section shows a close correlation (r = 0.93), while eccentric sites show lower correlation (r = 0.77).
- Wall morphology in CAD patients revealed increased leading edge thickness and altered ultrasound transmission characteristics.
Cite This Study
Nissen et al. (1991) studied this question.