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July 1, 1974Postgraduate Medical JournalOpen Access

Verapamil in the treatment of paroxysmal supraventricular tachycardia

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Key result

Intravenous verapamil promptly restored sinus rhythm in 100% of 32 patients with paroxysmal supraventricular tachycardia, demonstrating high efficacy across various supraventricular arrhythmias.

Why the study?

Does intravenous verapamil restore sinus rhythm in patients with paroxysmal supraventricular tachycardia?

Population

Patients with paroxysmal supraventricular tachycardia, supraventricular tachycardias associated with…

Design

Case_series

Follow-up

Immediate/prompt

Authors

DKD M KriklerUniversity of UlsterRSRoworth A.J. SpurrellSt Bartholomew's Hospital

Discussion

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Implication

May support IV verapamil for PSVT termination; hypothesis-generating and requires randomized confirmation before practice change.

Key Points

  • This research aims to evaluate the efficacy of verapamil in restoring sinus rhythm in patients with paroxysmal supraventricular tachycardia.
  • Administered intravenous verapamil at 10 mg to 32 patients with paroxysmal supraventricular tachycardia.
  • Assessed its effects in patients with Wolff-Parkinson-White syndrome and other tachycardias.
  • Monitored side effects and management associated with verapamil use.
  • Sinus rhythm achieved in all 32 patients with paroxysmal supraventricular tachycardia.
  • Conversion to sinus rhythm achieved in 15 of 18 patients with A-V junctional tachycardias.
  • Mild side effects noted; profound hypotension and bradycardia occurred rarely, tied to beta-blocker use or sinoatrial disease presence.

Structured PICO

Does intravenous verapamil restore sinus rhythm in patients with paroxysmal supraventricular tachycardia?

P
Population
Patients with paroxysmal supraventricular tachycardia and other supraventricular arrhythmias treated with intravenous verapamil.
I
Intervention
Verapamil 10 mg intravenously
O
Outcome
Conversion to sinus rhythmsurrogate

Intravenous verapamil is highly effective for promptly restoring sinus rhythm in patients with paroxysmal supraventricular tachycardia, particularly those due to circus movement.

Cite This Study

Krikler et al. (1974) studied Paroxysmal supraventricular tachycardia and other supraventricular arrhythmias. Verapamil was evaluated on Conversion to sinus rhythm. Intravenous verapamil promptly restored sinus rhythm in 100% of 32 patients with paroxysmal supraventricular tachycardia, demonstrating high efficacy across various supraventricular arrhythmias.

synapsesocial.com/papers/6a1fac9031c606dfff260d2ehttps://doi.org/10.1136/pgmj.50.585.447
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immediate effects of intravenous verapamil on atrial fibrillation1971 · 124 citations
  2. 2A fourth class of anti-dysrhythmic action? Effect of verapamil on ouabain toxicity, on atrial and ventricular intracellular potentials, and on other features of cardiac function1972 · 291 citations
  3. 3Action of verapamil on sinus node, atrioventricular, and intraventricular conduction.1973 · 117 citations
  4. 4The effect of Verapamil on the cardiac conduction system in man1974 · 80 citations
  5. 5Two or more intra AV nodal pathways in association with either a James or Kent extranodal bypass in 3 patients with paroxysmal supraventricular tachycardia.1973 · 84 citations