Profound Sinoatrial Arrest Associated with Ibrutinib
Key result
Ibrutinib is linked to profound sinoatrial arrest requiring permanent pacemaker implantation.
- n=1
Population
76-year-old Caucasian female with mantle cell lymphoma, hypertension, and gastroesophageal reflux disease…
Design
Case_report
Follow-up
Hospitalization
Authors
Discussion
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Member takes
Implication
May warrant heightened bradycardia surveillance on ibrutinib; leaves open causality and generalizability beyond this single case.
Study Design
Type
Case Report (n=1)
Multicenter
No
Structured PICO
P
Population
A 76-year-old female with mantle cell lymphoma who developed profound sinoatrial arrest requiring a permanent pacemaker after initiating ibrutinib.
E
Exposure
Ibrutinib 560 mg daily for 8 days
O
Outcome
Sinoatrial arrest and symptomatic bradycardiasafety
This case provides the first evidence associating ibrutinib use with profound bradycardia and sinoatrial arrest, highlighting a potentially life-threatening cardiac toxicity.
Limitations
- Patient may have had previously undiagnosed sick sinus syndrome or autonomic dysfunction
Cite This Study
Mathur et al. (2017) conducted a case report in Mantle cell lymphoma (n=1). Ibrutinib was evaluated on Sinoatrial arrest. Ibrutinib exposure was associated with profound sinoatrial arrest and symptomatic bradycardia requiring permanent pacemaker implantation in a 76-year-old female.