What is the clinical evidence from this study?

Study design: Other. Population: Heart failure. Intervention: Heart failure (chronic hyperadrenergic state). Primary outcome: RyR1 function and SR Ca2+ release.

March 10, 2003The Journal of Cell BiologyOpen Access

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle

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Key result

PKA hyperphosphorylation of RyR1 in skeletal muscle from animals with heart failure correlates with impaired SR Ca2+ release and early fatigue, suggesting a generalized EC coupling myopathy.

Authors

SRSteven ReikenElectrophysiology ALAlain LacampagneElectrophysiology HZHua ZhouPeking University

Discussion

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Implication

Does not yet inform clinical practice in heart failure; hypothesis-generating for skeletal EC coupling defects as a therapeutic target.

PICO

Population

Heart failure

Exposure / Comparator

Heart failure (chronic hyperadrenergic state)

Primary Outcome

RyR1 function and SR Ca2+ release

Cite This Study

Reiken et al. (2003) studied Heart failure. Heart failure (chronic hyperadrenergic state) was evaluated on RyR1 function and SR Ca2+ release. PKA hyperphosphorylation of RyR1 in skeletal muscle from animals with heart failure correlates with impaired SR Ca2+ release and early fatigue, suggesting a generalized EC coupling myopathy.

synapsesocial.com/papers/6a1fc133e9fc0c4c098aba75 https://doi.org/10.1083/jcb.200211012

Topics

Heart failure HFrEF treatment

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PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Topics

Also Consider