Why does cisplatin bind preferentially to GG units in oligonucleotides? The development of a new method which enables the determination of the four rate constants of the two-step reaction between an oligonucleotide containing a GpG unit and cis-[Pt(NH3)2(H2O)2]2+ has brought us closer to the solution of this puzzle.
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Gonnet et al. (1992) studied this question.
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