Key result
Phylogenetic analysis showed that 19 of 20 enteroviral sequences from patients with chronic fatigue syndrome were distinct from previously described enteroviruses causing acute infections.
Observational (n=20)
The study suggests persistence of distinct novel enterovirus sequences in some patients with chronic fatigue syndrome.
Suggests possible novel enteroviral persistence in CFS; leaves open causal role and need for confirmatory studies.
This study used phylogenetic analysis based on a region of the 5' non-translated region (5'NTR) of a variety of enteroviral sequences to compare sequences associated with chronic fatigue syndrome (CFS) and those from enteroviruses causing acute infections. Direct sequencing of PCR products was used to obtain the nucleic acid sequences from CFS patients. The inferred phylogenetic tree identified three groupings, one correlating with the diagnosis of CFS. The analysis identified a close relationship between the chronic fatigue enteroviral sequences, and showed that 19/20 were distinct from previously described enteroviruses. These results suggest there is persistence of enterovirus infection in some CFS patients and indicate the presence of distinct novel enterovirus sequences.
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Galbraith et al. (1995) conducted an observational in Chronic fatigue syndrome (n=20). Enteroviral sequences associated with chronic fatigue syndrome vs. Enteroviruses causing acute infections was evaluated on Phylogenetic relationship of enteroviral sequences. Phylogenetic analysis showed that 19 of 20 enteroviral sequences from patients with chronic fatigue syndrome were distinct from previously described enteroviruses causing acute infections.
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