Population
Cultured cells and muscle biopsy samples from patients with chronic fatigue syndrome
Comparison
Riboprobes complementary to positive or negative… vs Lytic infection of cultured cells
Design
Preclinical
Authors
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Suggests defective enteroviral RNA control enabling persistence in CFS muscle; leaves open causal role in symptoms and need for targeted studies.
Enterovirus persistence in muscle of chronic fatigue syndrome patients may be due to a defect in the control of viral RNA synthesis, leading to equal production of positive and negative strands.
Cunningham et al. (1990) studied this question.
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