Key result
The relative amounts of individual connexins and the number and size of gap junctions vary greatly across specific regions of the human heart, differing from patterns in previous animal studies.
Population
Human cardiac tissues including the sinoatrial node, adjacent atria, AV node, His bundle, bundle branches…
Design
Preclinical
Authors
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Regional human connexin heterogeneity differs from animal patterns; leaves open species-specific arrhythmia substrate modeling.
Observational
Connexin phenotypes vary significantly across different regions of the human heart and differ from animal models, which has important implications for understanding cardiac conduction and arrhythmia substrates.
Davis et al. (1995) conducted an observational in Cardiac conduction properties. Cardiac tissue regions was evaluated on Distribution and relative abundance of Cx37, Cx40, Cx43, Cx45, and Cx46. The relative amounts of individual connexins and the number and size of gap junctions vary greatly across specific regions of the human heart, differing from patterns in previous animal studies.
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