Key result
Primary negativity in the extracellular electrogram did not predict the site of the earliest or dominant pacemaker, reflecting instead the point where the impulse engages atrial myocardium.
Population
Six adult mongrel dogs (excised right atria perfused with Krebs-Henseleit solution)
Design
Preclinical
Authors
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Challenges electrogram-based pacemaker localization in models; hypothesis-generating for sinus node mapping in humans.
Primary negativity and sites of earliest activation reflect the point where the impulse engages atrial myocardium, not the site of earliest pacemaker activity, suggesting early extracellular activation represents exit sites from an insulated sinus node.
Bromberg et al. (1995) studied Normal sinus rhythm (n=6). Extracellular electrogram mapping was evaluated on Relationship of pacemaker action potentials to sites of earliest surface activation and local extracellular electrograms. Primary negativity in the extracellular electrogram did not predict the site of the earliest or dominant pacemaker, reflecting instead the point where the impulse engages atrial myocardium.
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