Tannic acid enhanced silk fibroin/hyaluronic acid hydrogel for In vitro hemostatic and antibacterial wound dressing

Natural polymeric hydrogels based on silk fibroin (SF) and hyaluronic acid (HA) offer promising biocompatible platforms for wound dressings, however, their clinical applications are limited by inadequate mechanical strength and a lack of multifunctionality. To overcome these limitations, we developed a dual-functionalized SF/HA hydrogel by incorporating quercetin (Q) as an antioxidant enhancer and tannic acid (TA) as a simultaneous mechanical reinforcement and antibacterial agent. The resulting SF/HA-QTA hydrogel exhibited exceptional multifunctionality