Signal Regulatory Protein α Deficiency Exacerbates Lipopolysaccharide-Induced Hypothermia and Hypometabolism in Mice

Key Points

• This study aims to understand the role of SIRPα in thermometabolic responses to lipopolysaccharide-induced hypothermia.
• Investigated thermometabolic changes in mice lacking SIRPα during LPS administration
• Measured body temperature and metabolic rates post-LPS exposure
• SIRPα deficiency resulted in significantly lower body temperatures following LPS treatment compared to control mice
• Increased hypometabolism was observed in SIRPα deficient mice when exposed to LPS