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Investigates thermometabolic effects of SIRPα deficiency during LPS challenge in mice, highlighting its role in temperature regulation.
Background and Aims: Hypothermia is observed after administration of high doses of lipopolysaccharide (LPS), yet the mechanisms underlying this response remain incompletely understood. We investigated whether loss of signal regulatory protein α (SIRPα), an inhibitory receptor expressed in macrophages and microglia, affects thermometabolic responses to systemic LPS challenge.
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Sato-Hashimoto et al. (2026) studied this question.
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