What question did this study set out to answer?

This study aims to understand the role of SIRPα in thermometabolic responses to lipopolysaccharide-induced hypothermia.

June 3, 2026The Kitakanto Medical Journal0 citationsOpen Access

Signal Regulatory Protein α Deficiency Exacerbates Lipopolysaccharide-Induced Hypothermia and Hypometabolism in Mice

MSMiho Sato-HashimotoKyushu University LAL AlkebsiNational Institutes for Quantum Science and Technology EUEriko UranoGunma University

Key Points

This study aims to understand the role of SIRPα in thermometabolic responses to lipopolysaccharide-induced hypothermia.
Investigated thermometabolic changes in mice lacking SIRPα during LPS administration
Measured body temperature and metabolic rates post-LPS exposure
SIRPα deficiency resulted in significantly lower body temperatures following LPS treatment compared to control mice
Increased hypometabolism was observed in SIRPα deficient mice when exposed to LPS

Abstract

Background and Aims: Hypothermia is observed after administration of high doses of lipopolysaccharide (LPS), yet the mechanisms underlying this response remain incompletely understood. We investigated whether loss of signal regulatory protein α (SIRPα), an inhibitory receptor expressed in macrophages and microglia, affects thermometabolic responses to systemic LPS challenge.

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