What question did this study set out to answer?

This study aims to investigate the metabolic and inflammatory changes induced by remote ischemic conditioning (RIC) to find new protective targets against ischemic injury.

June 3, 2026Journal of Cerebral Blood Flow & Metabolism

EXPRESS: Remote ischemic peconditioning and postconditioning reduced cerebral ischemic injury modulating inflammatory responses and metabolic pathways

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Authors

CTCoral Torres-QuerolBiomedical Research Institute of Lleida RPReinald PamplonaBiomedical Research Institute of Lleida GAGlòria ArquéUniversitat de Lleida

Discussion

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Implication

Randomized trial shows RIC reduces ischemic injury in a mouse model, suggesting new therapeutic targets.

Key Points

This study aims to investigate the metabolic and inflammatory changes induced by remote ischemic conditioning (RIC) to find new protective targets against ischemic injury.
Used a mouse model of transient focal cerebral ischemia with 60-minute distal middle cerebral artery occlusion.
Applied two RIC protocols: remote ischemic perconditioning (RIPerC) and remote ischemic postconditioning (RIPostC).
Analyzed plasma cytokines and metabolomic profiles using liquid chromatography-mass spectrometry (LC-MS) and statistical methods.
RIC significantly increased three plasma metabolites: Cer(42:3), HexCer(36:1), and TG(28:0).
Both RIPerC and RIPostC conferred neuroprotection, likely through regulation of peripheral immune responses.
Demonstrated moderate changes in brain metabolome, indicating systemic metabolic modulation during ischemia-reperfusion.

Cite This Study

Torres-Querol et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc44edee9eb8c0dce5d4d https://doi.org/10.1177/0271678x261458135

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June 3, 2026Journal of Cerebral Blood Flow & Metabolism

EXPRESS: Remote ischemic peconditioning and postconditioning reduced cerebral ischemic injury modulating inflammatory responses and metabolic pathways

View Full Paper

Ask AI

Bookmark

Authors

CTCoral Torres-QuerolBiomedical Research Institute of Lleida RPReinald PamplonaBiomedical Research Institute of Lleida GAGlòria ArquéUniversitat de Lleida

Discussion

Member takes

Implication

Randomized trial shows RIC reduces ischemic injury in a mouse model, suggesting new therapeutic targets.

Key Points

This study aims to investigate the metabolic and inflammatory changes induced by remote ischemic conditioning (RIC) to find new protective targets against ischemic injury.
Used a mouse model of transient focal cerebral ischemia with 60-minute distal middle cerebral artery occlusion.
Applied two RIC protocols: remote ischemic perconditioning (RIPerC) and remote ischemic postconditioning (RIPostC).
Analyzed plasma cytokines and metabolomic profiles using liquid chromatography-mass spectrometry (LC-MS) and statistical methods.
RIC significantly increased three plasma metabolites: Cer(42:3), HexCer(36:1), and TG(28:0).
Both RIPerC and RIPostC conferred neuroprotection, likely through regulation of peripheral immune responses.
Demonstrated moderate changes in brain metabolome, indicating systemic metabolic modulation during ischemia-reperfusion.

Cite This Study

Torres-Querol et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc44edee9eb8c0dce5d4d https://doi.org/10.1177/0271678x261458135

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