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May 9, 2019BMC GenomicsOpen Access

Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats

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Why the study?

Restoration of blood flow to ischemic myocardium salvages tissue but can induce ischemia-reperfusion injury, prompting investigation into the cardioprotective effects of remote ischemic postconditioning.

Does remote ischemic postconditioning reduce myocardial infarct size and apoptosis in a rat model of ischemia-reperfusion injury?

Population

In vivo rat model of myocardial ischemia-reperfusion injury

Comparison

Control vs IRI vs IRI + RPostC

Design

In vivo animal study

Authors

JWJunmin WenCZChuzhi ZhouZWZhiwei Wang

Discussion

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Overview

Provides mechanistic insights in rat IRI; leaves open translation to clinical cardioprotection.

Structured PICO

Does remote ischemic postconditioning reduce myocardial infarct size and apoptosis in a rat model of ischemia-reperfusion injury?

P
Population
24 specific pathogen-free grade Wistar male rats
I
Intervention
Remote ischemic postconditioning (RPostC) by three cycles of 30 s left femoral artery (LFA) occlusion/30 s reperfusion after 45 min of left anterior descending coronary artery (LAD) occlusion
C
Comparator
IRI group (45 min LAD occlusion and reperfusion without RPostC) and control group (no LAD occlusion)
O
Outcome
Myocardial infarct size (measured by TTC staining) and cardiomyocyte apoptosis level (measured by TUNEL assay)surrogate

Remote ischemic postconditioning reduces myocardial ischemia-reperfusion injury and apoptosis in rats, associated with changes in gene expression including TNF and Toll-like receptor signaling pathways.

Cite This Study

Wen et al. (2019) studied this question.

synapsesocial.com/papers/6a80c86f1257b045e13e98cfhttps://doi.org/10.1186/s12864-019-5743-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling2017 · 41 citations
  2. 2Remote ischemic post‑conditioning protects against myocardial ischemia/reperfusion injury by inhibiting the Rho‑kinase signaling pathway2019 · 13 citations
  3. 3Confined ischemia may improve remote myocardial outcome after rat cardiac arrest2013 · 4 citations
  4. 4Ischemic postconditioning alters the gene expression pattern of the ischemic heart2014 · 8 citations
  5. 5EXPRESS: Remote ischemic peconditioning and postconditioning reduced cerebral ischemic injury modulating inflammatory responses and metabolic pathways2026