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November 8, 2019Experimental and Therapeutic MedicineOpen Access

Remote ischemic post‑conditioning protects against myocardial ischemia/reperfusion injury by inhibiting the Rho‑kinase signaling pathway

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Why the study?

The study aimed to observe the effect of Rho-kinase on remote ischemic post-conditioning and explore the underlying mechanisms.

Does remote ischemic post-conditioning reduce myocardial ischemia/reperfusion injury in a rat model?

Population

32 male Sprague Dawley rats

Comparison

Sham vs ischemia/reperfusion vs RIPostC vs ischemia/reperfusion with fasudil

Design

Randomized animal study

Authors

JXJia XianHangzhou Dianzi UniversityQGQin GaoNingbo UniversityFNFang NiuMedtronic (Ireland)

Discussion

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Implication

May support Rho-kinase role in RIPostC cardioprotection in rats; leaves open clinical translation.

Structured PICO

Does remote ischemic post-conditioning reduce myocardial ischemia/reperfusion injury in a rat model?

P
Population
Male Sprague Dawley rats (n=32), weight 250-300 g, age 7-8 weeks.
I
Intervention
Remote ischemic post-conditioning (RIPostC) induced by three cycles of right femoral artery clamping for 5 min and declamping for 5 min prior to reperfusion, or fasudil (10 mg/kg IV) 5 min prior to reperfusion.
C
Comparator
Sham group (LAD threaded but not ligated) and ischemia/reperfusion (I/R) group (LAD ligated for 45 min followed by 180 min reperfusion).
O
Outcome
Myocardial infarct size, levels of CK, LDH, SOD, MDA, cTnI, and expression of ROCK1, ROCK2, Bcl-2, Bax, p-MYPT1, and p-MLC.surrogate

Remote ischemic post-conditioning protects against myocardial ischemia/reperfusion injury in rats, likely by inhibiting the Rho-kinase signaling pathway and reducing apoptosis.

Limitations

  • Did not investigate how RIPostC inhibits the Rho-kinase signaling pathway
  • Did not examine Rho-kinase changes with pharmacological intervention
  • Requires further analysis of cardiac function measurements and direct evaluation of apoptosis

Cite This Study

Xian et al. (2019) studied this question.

synapsesocial.com/papers/6a7cb016cc6f1443deba62a6https://doi.org/10.3892/etm.2019.8176
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)1996 · 2,050 citations
  2. 2Diagnostic markers of acute myocardial infarction2015 · 258 citations
  3. 3Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury2006 · 75 citations
  4. 4Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease2016 · 1,896 citations