Key result
Ischemic postconditioning alters ~108 genes tied to cellular metabolism in isolated rat hearts.
Why the study?
The gene expression changes induced by ischemic postconditioning in the ischemic heart were not fully characterized.
Does ischemic postconditioning alter gene expression patterns in isolated rat hearts following regional ischemia?
Population
Isolated rat hearts subjected to 30 min of regional ischemia
Comparison
Ischemic postconditioning during reperfusion vs reperfusion without postconditioning
Design
Preclinical experimental study with DNA microarray and QRT-PCR analysis
Follow-up
120 min of reperfusion
Authors
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Hypothesis-generating in rat models; leaves open whether metabolic gene changes mediate clinical postconditioning benefits.
Does ischemic postconditioning alter gene expression patterns in isolated rat hearts following regional ischemia?
Ischemic postconditioning alters the expression of numerous genes involved in cellular metabolic processes, revealing previously unsuspected mechanisms of cardioprotection.
Csonka et al. (2014) studied Ischemia/reperfusion injury. Ischemic postconditioning vs. Reperfusion without postconditioning was evaluated on Changes in gene expression. Ischemic postconditioning in isolated rat hearts significantly up-regulated 50 genes and down-regulated 58 genes, mostly related to cellular metabolic processes.
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