Safe, scalable and solvent-free acyl azide synthesis via continuous mechanochemistry

Key Points

• The study aims to develop a rapid and solvent-free method for synthesizing acyl azides using mechanochemistry.
• Utilized a custom single-screw reactor for mechanochemical synthesis.
• Conducted reactions under mild thermal conditions without solvents or additives.
• Employed continuous-flow technique to enhance reaction efficiency.
• Successfully synthesized acyl azides with high efficiency under mild conditions.
• Demonstrated the scalability of the process for larger batch production.
• Achieved solvent-free synthesis, reducing environmental impact.