Safe, scalable and solvent-free acyl azide synthesis via continuous mechanochemistry

Tabrez Shaikh; Arshad Hussain; Amol Kulkarni

doi:10.1039/d6gc01438k

January 1, 2026Green Chemistry

Safe, scalable and solvent-free acyl azide synthesis via continuous mechanochemistry

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Key Points

The study aims to develop a rapid and solvent-free method for synthesizing acyl azides using mechanochemistry.
Utilized a custom single-screw reactor for mechanochemical synthesis.
Conducted reactions under mild thermal conditions without solvents or additives.
Employed continuous-flow technique to enhance reaction efficiency.
Successfully synthesized acyl azides with high efficiency under mild conditions.
Demonstrated the scalability of the process for larger batch production.
Achieved solvent-free synthesis, reducing environmental impact.

Implication

Demonstrates solvent-free synthesis of acyl azides in a continuous-flow setup, highlighting its efficiency.

Abstract

Here we report a rapid, solvent- and additive-free, continuous-flow mechanochemical process for the synthesis of acyl azides (R–CO–N₃) using a custom single-screw reactor. The reaction operates under mild thermal conditions...

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Cite This Study

Shaikh et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc44edee9eb8c0dce5e25 https://doi.org/10.1039/d6gc01438k

View at Publisher

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Safe, scalable and solvent-free acyl azide synthesis via continuous mechanochemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

Safe, scalable and solvent-free acyl azide synthesis via continuous mechanochemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

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