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June 1, 2026Muscle & NerveOpen Access

Visible Tongue Fasciculations With Electromyographic Denervation in Autopsy‐Proven Progressive Supranuclear Palsy Mimicking Amyotrophic Lateral Sclerosis

Hiroyasu Inoue Yoshihiko Horimoto Yo Tsuda Yuta Madokoro Shoji Kawashima Akio Akagi Yasushi Iwasaki Noriyuki Matsukawa

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Key Points

This study aims to explore the presence of tongue fasciculations and denervation in progressive supranuclear palsy and how it mimics amyotrophic lateral sclerosis.
Case report detailing clinical findings of an autopsy-proven progressive supranuclear palsy case.
Electromyographic analyses were performed to assess denervation and fasciculations in the tongue.
Visible tongue fasciculations were documented, indicating muscle nerve involvement.
Electromyographic evidence confirmed denervation, showing overlap with ALS clinical features.

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Implication

Case report reveals tongue fasciculations and denervation in progressive supranuclear palsy, suggesting diagnostic overlap with ALS.

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Cite This Study

Inoue et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc47adee9eb8c0dce6039 https://doi.org/10.1002/mus.70308

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