What question did this study set out to answer?

Identify the site of origin and physiological mechanisms responsible for synchronous muscle fasciculations in motor neuron degeneration.

November 1, 1965Archives of Neurology

Synchronous Fasciculation in Motor Neuron Disease

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Identify the site of origin and physiological mechanisms responsible for synchronous muscle fasciculations in motor neuron degeneration.
Reviewed electrophysiological and pharmacological responses of fasciculating muscles to spinal anesthesia, peripheral nerve blocks, and curarization.
Tracked the abolition of muscle fasciculation following surgical nerve resection in patients with amyotrophic lateral sclerosis (N=3).
Curarization abolished fasciculation, whereas spinal and peripheral nerve anesthesia failed to stop contractions, indicating a site of hyperexcitability at distal nerve branches.
Surgical nerve resection in three patients eliminated fasciculations at 8, 11, and 12 days postoperatively, matching the expected time course of distal axon terminal degeneration.

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Implication

Neurophysiological study reveals peripheral origins of synchronous muscle twitching in motor neuron disease, suggesting neuromuscular junction hyperexcitability drives spontaneous firing.

Cite This Study

F. H. Norris (1965) studied this question.

synapsesocial.com/papers/6a770aac137c7dcc81bd923a https://doi.org/10.1001/archneur.1965.00470050043005

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Implication

Neurophysiological study reveals peripheral origins of synchronous muscle twitching in motor neuron disease, suggesting neuromuscular junction hyperexcitability drives spontaneous firing.

Synchronous Fasciculation in Motor Neuron Disease

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Discussion

Implication

Cite This Study

Synchronous Fasciculation in Motor Neuron Disease

Key Points

Discussion

Implication

Cite This Study

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