Novel bioactive metal-organic frameworks induce ferroptosis in cancer cells, suggesting improved therapy efficacy.
• Engineered a novel Cu-TCPP MOF-based nanoparticle to induce ferroptosis. • Enhanced ferroptosis via synergistic ROS generation and GSH depletion-triggered lipid peroxidation. • Provides a promising strategy to boost ferroptosis therapy efficacy in vivo .
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Huo et al. (2026) studied this question.