Higher Cardiometabolic Index was strongly correlated with reduced exercise capacity and independently associated with increased odds of HFpEF (OR 1.49; 95% CI 1.1-1.70).
Cross-Sectional (n=107)
Does a higher Cardiometabolic Index predict impaired exercise capacity and HFpEF in older patients with essential hypertension?
In older hypertensive patients, a higher Cardiometabolic Index is significantly associated with reduced exercise capacity and increased odds of having HFpEF.
Odds Ratio: 1.49 (95% CI 1.1–1.7)
Objective: Cardiometabolic Index (CMI) is a novel indicator that reflects visceral fat distribution and is associated with several risk factors for cardiovascular diseases (CVD). Exercise capacity is an important indicator of health status and longevity and reflects individuals’ functional reserve. This study aims to assess the impact of CMI on exercise capacity in patients with essential hypertension. Design and method: We included 107 patients > 65 years old with essential hypertension (55 male, 72 + 14 years old). They underwent a careful history, a detailed physical examination and an echocardiogram. In addition, all patients underwent a cardiopulmonary exercise testing (CPET) for the evaluation of exercise capacity. CMI was calculated as the product of the ratio of waist circumference to height (WHtR) and the ratio of triglyceride levels to high-density lipoprotein cholesterol levels (TG/HDL-C). Results: The mean exercise duration in our group was 9.2 ± 6.7 minutes, and the peak oxygen uptake (peak VO2) during CPET was 17.6 ± 6.9 mL/kg/min. Twenty-nine patients were presented with heart failure with preserved ejection fraction (HFpEF). Mean CMI was 3.7 ± 1.5. In addition, patients with high CMI have a lower exercise capacity score. CMI revealed a strong inverse correlation with exercise duration (r = - 0.56, p <0.001) and peakVO2 (r = - 0.65, p <0.001). Furthermore, patients with HFpEF had a higher CMI (4.2 ± 1.6 in patients with HFpEF versus 2.8 ± 1.8 in patients without HFpEF, p = 0.03), and CMI was independently associated with increased odds of HFpEF, with odds ratios of 1.49 (95% CI, 1.1-1.70). Conclusions: CMI has a significant impact on exercise capacity in patients with essential hypertension and is related with HFpEF presentation. CMI may be a simple and effective surrogate indicator and a modifiable biomarker of HFpEF in hypertensive patients.
Marketou et al. (Fri,) conducted a cross-sectional in Essential hypertension (n=107). Cardiometabolic Index (CMI) was evaluated on Heart failure with preserved ejection fraction (HFpEF) (OR 1.49, 95% CI 1.1-1.70). Higher Cardiometabolic Index was strongly correlated with reduced exercise capacity and independently associated with increased odds of HFpEF (OR 1.49; 95% CI 1.1-1.70).
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