3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

Muhammad Syafiq  Bin Shahari; Jacob P. Mahoney; Ziyue Wang; Anil Pant; Ajit Jagtap; Roshan Katekar; Jiashu Xie; Zhilong Yang; Zhengqiang Wang

doi:10.1039/d6md00285d

January 1, 2026RSC Medicinal Chemistry

3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

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Key Points

This study aims to explore the efficacy of 3-hydroxypyrimidine-2,4-dione derivatives as inhibitors of the monkeypox virus resolvase.
Developed an in vitro assay to measure the activity of orthopoxvirus resolvases.
Focused on the inhibition of monkeypox virus resolvase specifically.
Conducted tests on various 3-hydroxypyrimidine-2,4-dione derivatives.
Identified significant inhibition of monkeypox virus resolvase activity by specific derivatives.
Noted a reduction in viral genome replication with lower concentrations of the inhibitors.
Demonstrated potential for these compounds in developing antiviral therapies against monkeypox.

Implication

Evaluates 3-hydroxypyrimidine-2,4-dione inhibitors on monkeypox virus replication, suggesting a potential therapeutic strategy.

Abstract

Holliday junction resolvase plays an important role in poxvirus genome replication and viral maturation. Recently, we developed the first in vitro assay measuring the activity of orthopoxvirus resolvases, particularly monkeypox...

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Cite This Study

Shahari et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc64adee9eb8c0dce76f5 https://doi.org/10.1039/d6md00285d

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3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

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