Pain is a complex experience that encompasses both physical and emotional dimensions. Stomatognathic Pain (SP) affects the anatomical and functional structures of the stomatognathic system, which is involved in essential activities such as mastication, deglutition, and phonation. Consequently, SP can significantly impair patients’ quality of life, affecting physiological, psychological, and social well-being. Precision Medicine (PM) is an emerging patient-centered approach that enables healthcare providers to tailor diagnostic and therapeutic strategies according to each patient’s biochemical, physiological, environmental, and behavioral profile. The aim of this narrative review is to highlight PM tools for the diagnosis and treatment of SP and to explore their contribution to personalized management. A literature search was conducted in the PubMed and Scopus databases using the keywords “orofacial pain”, “stomatognathic pain”, “precision medicine”, “pain management”, “pain assessment”, “pain treatment”, and “patient-centered care”. Current evidence suggests that PM can improve SP management by identifying pathogenic mechanisms, clarifying disease etiology, and integrating advanced molecular and digital technologies. Emerging approaches, including genetic profiling, biomarker analysis, artificial intelligence–based diagnostics, targeted therapies, individualized rehabilitation, and behavioral interventions, may support personalized treatment and facilitate the development of patient-centered care models, ultimately reducing the burden of SP and improving clinical outcomes and quality of life.
Scribante et al. (2026) studied this question.