Key result
Rheumatoid arthritis was associated with significantly higher aortic pulse-wave velocity compared to controls (MD 1.32 m/s; 95% CI 0.77-1.88; P<0.00001), indicating increased arterial stiffness.
Why the study?
Is rheumatoid arthritis associated with increased arterial stiffness compared to controls?
Population
25 studies pooling 1,472 patients with rheumatoid arthritis (RA) and 1,583 controls
Comparison
Rheumatoid arthritis (disease state) vs Controls without rheumatoid arthritis
Design
Meta-analysis
Authors
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RA patients may benefit from earlier arterial stiffness assessment; supports PWV as a consistent CV risk marker across studies.
Meta-Analysis (n=3,055)
Is rheumatoid arthritis associated with increased arterial stiffness compared to controls?
Mean Difference: 1.32 (95% CI 0.77–1.88)
p-value: p=< 0.00001
Rheumatoid arthritis is associated with significantly increased arterial stiffness, a marker of cardiovascular risk, even in early-stage disease.
Ambrosino et al. (2015) conducted a meta-analysis in Rheumatoid arthritis (n=3,055). Rheumatoid arthritis vs. Controls was evaluated on aortic-PWV (MD 1.32 m/s, 95% CI 0.77, 1.88, p=< 0.00001). Rheumatoid arthritis was associated with significantly higher aortic pulse-wave velocity compared to controls (MD 1.32 m/s; 95% CI 0.77-1.88; P<0.00001), indicating increased arterial stiffness.
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