Key result
Patients with rheumatoid arthritis had significantly higher aortic stiffness, measured by pulse wave velocity, compared to the matched general population (7.687 vs 7.253 m/s, p=0.0087).
Why the study?
Do patients with rheumatoid arthritis have increased aortic stiffness compared to the general population?
Observational (n=151)
No
Do patients with rheumatoid arthritis have increased aortic stiffness compared to the general population?
Absolute Event Rate: 7.687% vs 7.253%
p-value: p=0.0087
Patients with rheumatoid arthritis have more pronounced arterial stiffness than the general population, driven by both traditional risk factors and disease duration.
Elevated aortic stiffness in RA signals potential CV vulnerability; leaves open whether PWV monitoring improves risk stratification.
The aim of this study was to compare the aortic stiffness in patients with rheumatoid arthritis (RA) with the aortic stiffness in general population (GP) and to evaluate the determinants of their stiffness. The study group consisted of 80 patients with RA and 71 matched GP. Pulse wave velocity (PWV) was assessed by Doppler ultrasonography. Biochemical analyses were conducted for serum using standard laboratory procedures. The mean PWV values were 7.687±1.03 versus 7.253±0.97 m/s in the patients with RA and GP, respectively. The average coordination of PWV and RA duration (RAD) variations is present by equation of linear regression: y =7.1309+0.0971x. By multiple regression analysis, C-reactive protein, ( β st =0.1096, P =0.0009), RAD ( β st =0.0917, P =0.0018), high-density lipoprotein cholesterol ( β st =‒1.0610, P =0.0271), and cholesterol ( β st =0.8491, P =0.0350) were independently associated with PWV in the patients with RA. C-reactive protein ( β st =0.1057, P =0.0016), triglycerides ( β st =0.1730, P =0.0117), low-density lipoprotein cholesterol ( β st =0.1467, P =0.0206), and cholesterol ( β st =0.0305, P =0.0261) were independently associated with PWV in the GP. Arterial stiffness was more pronounced in the patients with RA than in the GP. The independent determinants of arterial stiffness in both groups include traditional risk factors. RAD is determinant in patients with RA only.
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Avramovski et al. (2018) conducted an observational in Rheumatoid arthritis (n=151). Rheumatoid arthritis vs. General population was evaluated on Aortic stiffness assessed by pulse wave velocity (PWV) (p=0.0087). Patients with rheumatoid arthritis had significantly higher aortic stiffness, measured by pulse wave velocity, compared to the matched general population (7.687 vs 7.253 m/s, p=0.0087).
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