Observation on the efficacy of cognitive behavioral therapy combined with Tiaoshen and Kaiyu acupuncture in patients with post-stroke depression

May 1, 2026Lishizhen medicine and materia medica research

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Key Points

The central aim is to evaluate the effects of cognitive behavioral therapy combined with acupuncture on depression symptoms and related biomarkers in post-stroke depression patients.
116 post-stroke depression patients were randomly assigned to control and observation groups.
Control group received standard psychological care, while the observation group added cognitive behavioral therapy and acupuncture.
Outcome measures included depression scales and serum levels of BDNF and serotonin before and after an 8-week intervention.
Both groups showed significant improvements in depression scores and increases in BDNF and serotonin levels post-treatment (P<0.05).
The observation group outperformed the control group in both symptom reduction and biomarker improvement (P<0.05).
The total effective rate was 96.55% in the observation group compared to 79.31% in the control group (P=0.010).

Investigates the impact of combined therapies on depression and biomarkers in patients.

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RAO et al. (2026) studied this question.

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