What is the clinical evidence from this study?

Study design: Observational. Population: Acute myocardial infarction (n=58499). Intervention: History of hypertension vs. No history of hypertension. Primary outcome: Average in-hospital mortality (OR 0.92, 95% CI 0.83-1.02, p=0.099).

What question did this study set out to answer?

This study analyzes mortality trends in acute myocardial infarction patients based on their history of hypertension.

June 3, 2026Journal of Hypertension

Mortality Trends in Acute Myocardial Infarction Patients With and Without a History of Hypertension

View Full Paper

Ask AI

Bookmark

Key result

History of hypertension is not linked to in-hospital mortality in patients with AMI.

OR 0.92
95% CI 0.83-1.02
P=0.099
n=58,499

Why the study?

Previous studies reported conflicting findings regarding short-term outcomes in acute myocardial infarction (AMI) patients with and without a history of hypertension.

Does a history of hypertension affect in-hospital and 1-year mortality in patients with acute myocardial infarction?

Key Points

This study analyzes mortality trends in acute myocardial infarction patients based on their history of hypertension.
Included AMI patients from the Swiss AMIS Plus registry (2000-2025)
Plotted mortality rates by admission year, adjusted for various factors
Conducted a subgroup analysis of 1-year follow-up for available patients
In-hospital mortality was higher in patients with hypertension (5.5% vs 3.4%)
Adjusted analysis showed no significant difference in mortality rates (OR 0.92, 95% CI 0.83-1.02, p=0.099)
1-year mortality showed a higher crude rate for hypertensive patients but was not significant after adjustment (OR 0.93, 95% CI 0.73-1.17, p=0.521)

Study Design

Type

Observational (n=58,499)

Multicenter

Yes

Structured PICO

Does a history of hypertension affect in-hospital and 1-year mortality in patients with acute myocardial infarction?

Population

Approximately 58,499 acute myocardial infarction patients enrolled in the Swiss AMIS Plus registry between 2000 and 2025, evaluated for the impact of a history of hypertension on mortality.

Exposure

History of hypertension

Comparator

No history of hypertension

Outcome

In-hospital mortality and 1-year mortalityhard clinical

Main Result

Odds Ratio: 0.92 (95% CI 0.83–1.02)

Absolute Event Rate: 5.5% vs 3.4%

p-value: p=0.099

After adjusting for baseline differences, a history of hypertension does not significantly impact in-hospital or 1-year mortality in patients presenting with acute myocardial infarction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No independent mortality link after adjustment in AMI; leaves open residual confounding in observational data.

Cite This Study

Foster-Witassek et al. (2026) conducted an observational in Acute myocardial infarction (n=58,499). History of hypertension vs. No history of hypertension was evaluated on Average in-hospital mortality (OR 0.92, 95% CI 0.83-1.02, p=0.099). A history of hypertension in patients with acute myocardial infarction was not significantly associated with average in-hospital mortality after adjustment (OR 0.92; 95% CI 0.83-1.02; p=0.099).

synapsesocial.com/papers/6a1fc76ddee9eb8c0dce8585 https://doi.org/10.1097/01.hjh.0001195864.70408.fa

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Mortality Trends in Acute Myocardial Infarction Patients With and Without a History of Hypertension

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Mortality Trends in Acute Myocardial Infarction Patients With and Without a History of Hypertension

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider