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May 1, 1994Journal of VirologyOpen Access

Identification of minireovirus as a Norwalk-like virus in pediatric patients with gastroenteritis

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Key result

Sequence analysis of a minireovirus isolate showed 52% nucleotide sequence identity with Norwalk virus, indicating it should be included in the Caliciviridae family.

Population

Infants and young children with gastroenteritis (source of minireovirus clinical isolate)

Design

Preclinical

Authors

JLJudy LewCenters for Disease Control and PreventionMPM PetrićHealth CanadaAKAlbert Z. KapikianUniversity of Nebraska–Lincoln

Discussion

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Implication

Updates minireovirus taxonomy in gastroenteritis; leaves open human pathogenicity confirmation from animal data.

Structured PICO

P
Population
Infants and young children with gastroenteritis (source of minireovirus clinical isolate)
E
Exposure
Sequence analysis of approximately 2,800 consecutive bases derived from overlapping PCR clones
O
Outcome
Nucleotide sequence identity and genomic organization comparison with Norwalk virus

Minireovirus, previously identified by electron microscopy in pediatric gastroenteritis, is genetically classified as a Norwalk-like virus within the Caliciviridae family.

Cite This Study

Lew et al. (1994) studied gastroenteritis. Minireovirus vs. Norwalk virus was evaluated on Nucleotide sequence identity. Sequence analysis of a minireovirus isolate showed 52% nucleotide sequence identity with Norwalk virus, indicating it should be included in the Caliciviridae family.

synapsesocial.com/papers/6a1fc8052be0c1f4e3bb4183https://doi.org/10.1128/jvi.68.5.3391-3396.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pediatric viral gastroenteritis during eight years of study1983 · 240 citations
  2. 2Sequence diversity of small, round-structured viruses in the Norwalk virus group1994 · 244 citations
  3. 3Visualization by Immune Electron Microscopy of a 27-nm Particle Associated with Acute Infectious Nonbacterial Gastroenteritis1972 · 1,134 citations
  4. 4Detection by Immune Electron Microscopy of the Snow Mountain Agent of Acute Viral Gastroenteritis1982 · 121 citations
  5. 5Comparison of the reactivities of baculovirus-expressed recombinant Norwalk virus capsid antigen with those of the native Norwalk virus antigen in serologic assays and some epidemiologic observations1993 · 215 citations