Key result
Obesity (BMI ≥ 30) was associated with a higher crude in-hospital mortality rate (10.9% vs 7.6%, OR 1.47) compared to normal weight, but this effect was eliminated after adjusting for comorbidities.
Why the study?
The presentation and in-hospital outcomes of obese patients hospitalized for cardiovascular diseases in a Middle Eastern country remained to be characterized.
Does obesity affect presentation and in-hospital mortality in patients hospitalized with acute cardiovascular disorders?
Cohort (n=7,284)
No
Does obesity affect presentation and in-hospital mortality in patients hospitalized with acute cardiovascular disorders?
Odds Ratio: 1.47 (95% CI 1.25–1.74)
Absolute Event Rate: 10.9% vs 7.6%
p-value: p=0.001
Obesity is common among patients hospitalized for acute cardiovascular disorders and is associated with higher crude in-hospital mortality, though this is driven by comorbidities rather than BMI itself.
Background: We aimed to study the presentation and in-hospital outcomes of obese patients hospitalized for cardiovascular diseases (CVDs) in a Middle Eastern country. Methods: This retrospective study included patients admitted to the Heart Hospital between 2015 and 2020. Patients were divided according to their body mass index (BMI): Group I (BMI 18.5–24.9), Group II (BMI 25–29.9), and Group III (BMI ≥ 30), by applying one-way ANOVAs and chi-square tests. The obese group (BMI ≥ 30) was graded and compared (Grade I (BMI 30–34.9), Grade II (BMI 35–39.9), and Grade III (BMI ≥ 40)). Results: There were 7284 patients admitted with CVDs (Group I (29%), Group II (37%), and Group III (34%)). The mean age was higher in Group III than Groups I and II (p < 0.001). Male sex was predominant in all groups except for morbid obesity (Grade III), in which females predominated. Diabetes mellitus (DM), hypertension, and dyslipidemia were more common in Group III. Chest pain was more common in Group II, while shortness of breath was more evident in Group III (p < 0.001). Group II had more ST-elevation myocardial infarction (STEMI), followed by Group I (p < 0.001). Atrial fibrillation (AF) was observed more frequently in Group III (p < 0.001). Congestive heart failure (CHF) was common in Group III (19%) (p < 0.001). In the subanalysis, (Grade I (62%), Grade II (22.5%), and Grade III (15.5%)), Grade I had more STEMI, whereas AF and CHF were higher in Grade III (p < 0.001). Percutaneous Coronary Intervention was performed less frequently in Grade III (p < 0.001). In-hospital mortality was higher in Grade III (17.1%), followed by Grades II (11.2%) and I (9.3%) (p < 0.001). Conclusions: In this study, one third of the hospitalized CVS patients were obese. AF and CHF with preserved EF were the most common cardiovascular presentations in obese patients. In patients with CVDs, obesity was associated with higher rates of comorbidities and in-hospital mortality. However, obesity measured by BMI alone was not an independent predictor of mortality in obese cardiac patients.
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Abid et al. (2023) conducted a cohort in Acute Cardiovascular Disorders (n=7,284). Obesity (BMI ≥ 30) vs. Normal weight (BMI 18.5-24.9) and Overweight (BMI 25-29.9) was evaluated on In-hospital mortality (OR 1.47, 95% CI 1.25-1.74, p=0.001). Obesity (BMI ≥ 30) was associated with a higher crude in-hospital mortality rate (10.9% vs 7.6%, OR 1.47) compared to normal weight, but this effect was eliminated after adjusting for comorbidities.
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