What question did this study set out to answer?

The study aims to assess the impact of exercise training on coronary vasomotor reactivity in dogs.

March 1, 1985CirculationOpen Access

Proximal coronary vasomotor reactivity after exercise training in dogs.

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Why the study?

Does exercise training attenuate epicardial coronary vasoconstrictor responses in dogs?

Population

14 dogs (8 trained, 6 nontrained controls)

Comparison

Exercise training by treadmill running for 8 weeks vs No exercise training (nontrained controls)

Design

Preclinical

Follow-up

8 weeks

Authors

ABA. A. BoveTemple University JDJerry DeweyMayo Clinic

Discussion

Member takes

Implication

Supports hypothesis of exercise-modulated coronary tone in canines; leaves open translation to human epicardial arteries.

Key Points

The study aims to assess the impact of exercise training on coronary vasomotor reactivity in dogs.
Eight dogs underwent treadmill training for 8 weeks; six dogs were controls.
Heart rate and plasma norepinephrine and epinephrine levels were measured post-exercise.
Coronary responses were evaluated using quantitative coronary angiography and radioactive microspheres.
Trained dogs showed significantly lower resting norepinephrine (142 +/- 30 pg/ml) and epinephrine (258 +/- 45 pg/ml) compared to controls (p<0.05).
Attenuated constrictive responses to phenylephrine in trained dogs compared to nontrained dogs, while serotonin response remained unchanged.

Structured PICO

Does exercise training attenuate epicardial coronary vasoconstrictor responses in dogs?

Population

14 dogs (8 trained, 6 nontrained controls)

Intervention

Exercise training by treadmill running for 8 weeks

Comparator

No exercise training (nontrained controls)

Outcome

Epicardial coronary responses to intracoronary infusion of serotonin and phenylephrine evaluated by quantitative coronary angiographysurrogate

Endurance exercise training attenuates epicardial coronary vasoconstriction in response to alpha-adrenergic stimulation in a canine model.

Cite This Study

Bove et al. (1985) studied this question.

synapsesocial.com/papers/6a1fc957117dfefbb99899bc https://doi.org/10.1161/01.cir.71.3.620

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Proximal coronary vasomotor reactivity after exercise training in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Proximal coronary vasomotor reactivity after exercise training in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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