What question did this study set out to answer?

This study aims to evaluate how exercise training influences the sensitivity of epicardial coronary arteries to various agonists.

December 1, 1991Journal of Applied Physiology

Exercise training and responsiveness of isolated coronary arteries

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Why the study?

Does exercise training alter the responsiveness of isolated coronary arteries to vasoactive substances in male dogs?

Population

Male dogs capable of running on a treadmill

Comparison

Exercise training for 11 weeks vs Sedentary group

Design

Preclinical, separated randomly into two groups

Follow-up

11 weeks

Authors

PRPaul J. RogersMayo Clinic TMT. MillerMayo Clinic BBBrent A. BauerMayo Clinic

Discussion

Member takes

Implication

Caution against clinical extrapolation from canine coronaries; leaves open human vascular responsiveness to exercise training.

Key Points

This study aims to evaluate how exercise training influences the sensitivity of epicardial coronary arteries to various agonists.
Isolated coronary arteries from male dogs were assessed after 11 weeks of exercise training.
Dogs were randomly assigned to sedentary or exercise training groups.
Contractions and responses to various adrenergic and vasoactive intestinal polypeptide agonists were measured in vitro.
Contractions to alpha 1-adrenergic agonists were unaffected by exercise training.
Endothelium-dependent relaxations to alpha 2-adrenergic agonists showed no significant reduction after training.
Responses to beta-adrenergic agonists and vasoactive intestinal polypeptide were significantly decreased after training.

Structured PICO

Does exercise training alter the responsiveness of isolated coronary arteries to vasoactive substances in male dogs?

Population

Male dogs capable of running on a treadmill

Intervention

Exercise training for 11 weeks

Comparator

Sedentary group

Outcome

In vitro responsiveness of isolated left circumflex and left anterior descending coronary artery rings to alpha- and beta-adrenergic agonists, vasoactive intestinal polypeptide, and substance Psurrogate

Exercise training decreases the responsiveness of canine coronary vascular smooth muscle to beta-adrenergic agonists and vasoactive intestinal polypeptide.

Cite This Study

Rogers et al. (1991) studied this question.

synapsesocial.com/papers/6a1fc957117dfefbb99899b6 https://doi.org/10.1152/jappl.1991.71.6.2346

Topics

Thymosin beta-4

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