What question did this study set out to answer?

To determine whether exercise training boosts the contribution of multiple endothelial mediators to coronary artery relaxation in the setting of chronic coronary occlusion.

August 31, 2013AJP Heart and Circulatory PhysiologyOpen Access

Exercise training enhances multiple mechanisms of relaxation in coronary arteries from ischemic hearts

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Why the study?

Does exercise training enhance endothelium-dependent relaxation in coronary arteries in a swine model of chronic coronary artery occlusion?

Population

Yucatan miniature swine with chronic coronary artery occlusion induced by an ameroid constrictor placed…

Comparison

Exercise training for 14 weeks vs Sedentary regimen for 14 weeks

Design

Preclinical, randomly assigned

Follow-up

14 weeks

Authors

RDRachel DeerThe University of Texas Medical Branch at Galveston CHCristine L. HeapsTexas A&M University

Discussion

Member takes

Implication

May support exercise to enhance coronary endothelial function in ischemia; leaves open human translation.

Key Points

To determine whether exercise training boosts the contribution of multiple endothelial mediators to coronary artery relaxation in the setting of chronic coronary occlusion.
Yucatan miniature swine underwent placement of an ameroid constrictor around the proximal left circumflex coronary artery to induce gradual chronic occlusion.
At 8 weeks postoperatively, swine were randomly assigned to either a sedentary lifestyle or a treadmill exercise regimen (5 days/week) for 14 weeks.
Endothelium-dependent relaxation, nitric oxide levels, prostaglandin I2 production, and BKCa channel function were assessed in nonoccluded and collateral-dependent arteries.
Exercise training significantly increased the contribution of nitric oxide, prostanoids, and BKCa channels to bradykinin-mediated relaxation in both nonoccluded and collateral-dependent arteries.
Combined inhibition of nitric oxide synthase, prostanoids, and BKCa channels completely ablated the exercise-induced improvements in coronary relaxation.
Bradykinin-stimulated nitric oxide production increased in endothelial cells from exercise-trained swine, whereas BKCa currents, BKCa protein levels, and cyclic nucleotide levels showed no significant differences.

Structured PICO

Does exercise training enhance endothelium-dependent relaxation in coronary arteries in a swine model of chronic coronary artery occlusion?

Population

Yucatan miniature swine with chronic coronary artery occlusion induced by an ameroid constrictor placed around the proximal left circumflex coronary artery

Intervention

Exercise training (treadmill, 5 days/wk) for 14 weeks

Comparator

Sedentary regimen for 14 weeks

Outcome

Endothelium-dependent, bradykinin-mediated relaxation in nonoccluded and collateral-dependent arteriessurrogate

Exercise training enhances endothelium-dependent relaxation in ischemic hearts through the upregulation of parallel vasodilator pathways including nitric oxide, prostanoids, and BKCa channels.

Cite This Study

Deer et al. (2013) studied this question.

synapsesocial.com/papers/6a8bfa6beada60f85de3d2de https://doi.org/10.1152/ajpheart.00531.2013

Topics

Women and heart disease

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Exercise training enhances multiple mechanisms of relaxation in coronary arteries from ischemic hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Exercise training enhances multiple mechanisms of relaxation in coronary arteries from ischemic hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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