Key result
Exercise training significantly enhanced sustained relaxation to bradykinin in small coronary arteries of control and ischemic swine hearts via increased nitric oxide contribution.
Why the study?
Does exercise training improve sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease?
Population
Yucatan swine designated to a control group or an ischemic heart disease model
Comparison
Exercise training (five days/week for 16 weeks) vs Sedentary (SED) regimen
Design
Preclinical
Follow-up
16 weeks
Authors
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Hypothesis-generating in swine; leaves open whether exercise training improves coronary endothelial function in human ischemic heart disease.
Does exercise training improve sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease?
Exercise training enhances sustained endothelium-dependent relaxation in small coronary arteries of both healthy and ischemic hearts via increased nitric oxide contribution and endothelial calcium responses.
Heaps et al. (2014) studied Ischemic heart disease (porcine model). Exercise training vs. Sedentary (SED) regimen was evaluated on Sustained relaxation to persistent endothelium-dependent vasodilator exposure (bradykinin). Exercise training significantly enhanced sustained relaxation to bradykinin in small coronary arteries of control and ischemic swine hearts via increased nitric oxide contribution.
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