Key result
Exercise training significantly enhanced bradykinin-mediated dilation in collateral-dependent coronary arterioles compared with sedentary pigs, involving NO and superoxide/H2O2 pathways.
Why the study?
Does exercise training improve endothelium-mediated dilation via NO and superoxide/H2O2 signaling in collateral-dependent porcine coronary arterioles?
Population
Yucatan miniature swine with gradual chronic coronary artery occlusion induced by an ameroid constrictor…
Comparison
Exercise training starting 8 weeks postoperatively vs Sedentary (pen-confined) regimen
Design
Preclinical, Randomly assigned
Follow-up
14 weeks
Authors
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Warrants human mechanistic studies of exercise in coronary disease; leaves open clinical translation of these pathways.
RCT
Randomly assigned
Does exercise training improve endothelium-mediated dilation via NO and superoxide/H2O2 signaling in collateral-dependent porcine coronary arterioles?
Exercise training enhances endothelium-mediated dilation in collateral-dependent coronary arterioles through both nitric oxide and superoxide/H2O2 signaling pathways in a porcine model.
Xie et al. (2012) conducted an RCT in Chronic coronary artery occlusion. Exercise training vs. Sedentary (pen-confined) was evaluated on Concentration-dependent, bradykinin-mediated dilation in cannulated collateral-dependent arterioles. Exercise training significantly enhanced bradykinin-mediated dilation in collateral-dependent coronary arterioles compared with sedentary pigs, involving NO and superoxide/H2O2 pathways.
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