Why the study?
Does exercise training improve endothelium-mediated relaxation and ecNOS mRNA levels in collateral-dependent coronary arterioles in a porcine model of chronic coronary occlusion?
Population
Adult female miniature swine subjected to chronic, progressive ameroid occlusion of the proximal left…
Comparison
16-week exercise-training (treadmill running) vs Sedentary protocol (cage confinement)
Design
Preclinical, Randomly exposed to exercise or sedentary protocols
Follow-up
16 weeks
Authors
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Supports exercise benefits on coronary microvasculature in animal occlusion models; leaves open translation to human chronic coronary disease.
Does exercise training improve endothelium-mediated relaxation and ecNOS mRNA levels in collateral-dependent coronary arterioles in a porcine model of chronic coronary occlusion?
Exercise training improves endothelium-dependent relaxation and normalizes ecNOS mRNA expression in collateral-dependent coronary microvasculature following chronic occlusion in a porcine model.
Griffin et al. (2001) studied this question.
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