What question did this study set out to answer?

The aim is to evaluate how daily exercise affects the sensitivity of coronary resistance vessels to pharmacological activation.

January 1, 1989Journal of Applied Physiology

Daily exercise enhances coronary resistance vessel sensitivity to pharmacological activation

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Why the study?

Does daily exercise enhance coronary resistance vessel sensitivity to pharmacological activation in conscious dogs?

Population

12 conscious adult mongrel dogs

Comparison

Daily exercise vs Baseline state and state after left stellate…

Design

Preclinical

Authors

SDStephen E. DiCarloPhiladelphia College of Osteopathic Medicine RBRobert W. BlairTulane University VBV. S. BishopBishop's University

Discussion

Member takes

Implication

Exercise-induced coronary adaptations appear neurally dependent in canines; leaves open translation to human coronary physiology.

Key Points

The aim is to evaluate how daily exercise affects the sensitivity of coronary resistance vessels to pharmacological activation.
Evaluated 12 conscious adult mongrel dogs through intracoronary infusion of pharmacological agents.
Measured effects on coronary blood flow velocity in relation to alpha and beta adrenergic receptor activation.
Assessed the influence of left stellate ganglionectomy on vascular sensitivity post-exercise.
Daily exercise significantly enhanced coronary vascular sensitivity to pharmacological agents.
Alpha-adrenergic agents decreased coronary blood flow velocity, while beta-adrenergic and metabolic vasodilators increased it.
After ganglionectomy, daily exercise did not enhance vascular sensitivity, indicating neurogenic influence.

Structured PICO

Does daily exercise enhance coronary resistance vessel sensitivity to pharmacological activation in conscious dogs?

Population

12 conscious adult mongrel dogs

Intervention

Daily exercise

Comparator

Baseline state (no daily exercise) and state after left stellate ganglionectomy

Outcome

Coronary resistance vessel sensitivity to intracoronary infusion of pharmacological agents (measured by coronary blood flow velocity)surrogate

Daily exercise induces a nonspecific potentiation of coronary vascular sensitivity to pharmacological activation, an adaptation that requires an intact nervous system.

Cite This Study

DiCarlo et al. (1989) studied this question.

synapsesocial.com/papers/6a1fc957117dfefbb99899b8 https://doi.org/10.1152/jappl.1989.66.1.421

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Daily exercise enhances coronary resistance vessel sensitivity to pharmacological activation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Daily exercise enhances coronary resistance vessel sensitivity to pharmacological activation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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