Development of Predictive Models for Long-Term Cardiovascular Risk Associated With Systolic and Diastolic Blood Pressure
Key result
Lower levels of systolic and diastolic blood pressure predicted lower cardiovascular event rates without a plateau, with both SBP and DBP significant in males (P<0.001) and SBP in females (P<0.001).
Why the study?
Do systolic and diastolic blood pressure levels independently predict long-term cardiovascular risk in men and women?
Population
61,947 adults from two clinical trial cohorts: 22,071 males from the Physicians' Health Study and 39,876…
Design
Cohort
Follow-up
median 13.0 years (males) and 6.2 years (females)
Authors
Discussion
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Member takes
Implication
Caution against changing targets from observational data alone; leaves open whether intensive BP lowering improves outcomes in trials.
Study Design
Type
Cohort (n=61,947)
Structured PICO
Do systolic and diastolic blood pressure levels independently predict long-term cardiovascular risk in men and women?
P
Population
61,947 participants from two large cohorts (22,071 males followed for a median of 13.0 years and 39,876 females followed for a median of 6.2 years) assessed for cardiovascular risk associated with blood pressure.
E
Exposure
Systolic and diastolic blood pressure levels
O
Outcome
Composite of myocardial infarction, stroke, coronary artery bypass, angioplasty, and cardiovascular deathcomposite
Main Result
p-value: p=<0.001
Lower blood pressure is continuously associated with reduced cardiovascular risk without a J-curve, with systolic blood pressure being a stronger predictor, especially in women.
Cite This Study
Glynn et al. (2002) conducted a cohort in Cardiovascular risk (n=61,947). Systolic and diastolic blood pressure vs. Lower levels of blood pressure was evaluated on Myocardial infarction, stroke, coronary artery bypass, angioplasty, and cardiovascular death (p=<0.001). Lower levels of systolic and diastolic blood pressure predicted lower cardiovascular event rates without a plateau, with both SBP and DBP significant in males (P<0.001) and SBP in females (P<0.001).