Key result
Bioengineered extracellular vesicles offer promising therapeutic and diagnostic potential for cardiovascular diseases, though clinical application is limited by isolation and delivery challenges.
Why the study?
Despite advances in CVD diagnosis and interventions, multifaceted therapeutics are needed, and the clinical application of extracellular vesicles is limited by challenges in isolation, standardization, and delivery.
Bioengineered extracellular vesicles offer a novel multifaceted therapeutic and diagnostic approach for cardiovascular diseases, pending the resolution of translational challenges.
Requires resolution of isolation and delivery challenges before clinical consideration in CVD; leaves open therapeutic translation pathways.
Cardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide. Despite recent advances in diagnosis and interventions, there is still a crucial need for new multifaceted therapeutics that can address the complicated pathophysiological mechanisms driving CVD. Extracellular vesicles (EVs) are nanovesicles that are secreted by all types of cells to transport molecular cargo and regulate intracellular communication. EVs represent a growing field of nanotheranostics that can be leveraged as diagnostic biomarkers for the early detection of CVD and as targeted drug delivery vesicles to promote cardiovascular repair and recovery. Though a promising tool for CVD therapy, the clinical application of EVs is limited by the inherent challenges in EV isolation, standardization, and delivery. Hence, this review will present the therapeutic potential of EVs and introduce bioengineering strategies that augment their natural functions in CVD.
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Ramasubramanian et al. (2022) conducted a review in Cardiovascular Diseases. Bioengineered Extracellular Vesicles was evaluated. Bioengineered extracellular vesicles offer promising therapeutic and diagnostic potential for cardiovascular diseases, though clinical application is limited by isolation and delivery challenges.
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