January 31, 2004AJP Heart and Circulatory Physiology
MRI and echocardiographic assessment of the diastolic dysfunction of normal aging: altered LV pressure decline or load?
Why the study?
Does normal aging affect left ventricular pressure decline or left atrial pressure as assessed by MRI and echocardiography?
Structured PICO
Does normal aging affect left ventricular pressure decline or left atrial pressure as assessed by MRI and echocardiography?
P
Population
122 normal subjects aged 21-92 years
I
Intervention
Assessment by Doppler echocardiography and MRI
O
Outcome
Relation of age to parameters reflecting the rate of left ventricular pressure (LVP) decline and left atrial pressure (LAP)surrogate
Reduced early filling in older adults may be more closely related to a reduced early diastolic left atrial pressure than to slower left ventricular pressure decline.
Authors
Discussion
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Implication
Age-related diastolic changes may reflect reduced early LA pressure more than impaired LV relaxation; leaves open causal mechanisms and clinical relevance.
Cite This Study
Hees et al. (2004) studied this question.