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January 1, 1994Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells.

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Why the study?

Do cytokines decrease the hepatic synthesis and secretion of apolipoproteins in Hep G2 cells?

Population

Hep G2 cells

Comparison

Incubation with human recombinant tumor necrosis… vs Control

Design

Preclinical

Follow-up

24 hours

Authors

WEWalter H. EttingerUniversity of Massachusetts Chan Medical SchoolVVVarma VkPost Graduate Institute of Medical Education and ResearchMSMary G. Sorci‐ThomasMedical College of Wisconsin

Discussion

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Implication

May explain inflammation-associated hypocholesterolemia; hypothesis-generating from Hep G2 model, needs in vivo confirmation.

Structured PICO

Do cytokines decrease the hepatic synthesis and secretion of apolipoproteins in Hep G2 cells?

P
Population
Hep G2 cells
I
Intervention
Incubation with human recombinant tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6
C
Comparator
Control (implied, cells not incubated with cytokines)
O
Outcome
Concentrations of apolipoprotein (apo) A-I, apoB, and lecithin:cholesterol acyltransferase (LCAT) activity in the medium after 24 hours of incubationsurrogate

Cytokines decrease the hepatic synthesis and/or secretion of apolipoproteins in Hep G2 cells, providing a potential mechanism for acquired hypocholesterolemia during acute and chronic inflammation.

Cite This Study

Ettinger et al. (1994) studied this question.

synapsesocial.com/papers/6a1fd40d663eb9633f117aa6https://doi.org/10.1161/01.atv.14.1.8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen1980 · 2,053 citations
  2. 2Pathogenesis of carbohydrate-induced hypertriglyceridemia using HepG2 cells as a model system.1992 · 55 citations
  3. 3Measurement of apolipoprotein A-I concentration in nonhuman primate serum by enzyme-linked immunosorbent assay (ELISA).1983 · 96 citations
  4. 4Synthesis and regulation of acute phase plasma proteins in primary cultures of mouse hepatocytes.1983 · 96 citations
  5. 5Apolipoprotein (apo) A-I production and mRNA abundance explain plasma apoA-I and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia.1988 · 90 citations