Key result
Higher awake systolic blood pressure index was independently associated with concentric hypertrophy in children and adolescents with primary hypertension (OR 1.07; 95% CI 1.001-1.14; P=0.045).
Why the study?
Limited information is available regarding the relationship between ambulatory blood pressure monitoring and cardiac geometry in hypertensive children.
Do ambulatory blood pressure monitoring parameters predict left ventricular cardiac geometry in children with primary hypertension?
Observational (n=119)
Do ambulatory blood pressure monitoring parameters predict left ventricular cardiac geometry in children with primary hypertension?
Odds Ratio: 1.07 (95% CI 1.001–1.14)
p-value: p=0.045
Ambulatory blood pressure monitoring parameters, including awake and sleep systolic BP loads, are independent predictors of concentric left ventricular hypertrophy in children with primary hypertension.
Supports awake SBP index association with concentric hypertrophy in pediatric hypertension; leaves open prospective validation for risk stratification.
Limited information is available regarding the relationship between ambulatory blood pressure monitoring (ABPM) and cardiac geometry in hypertensive children. ABPM and 2D-echocardiography were retrospectively reviewed in children and adolescents <21 years old with primary hypertension. A total of 119 participants (median age 15.0 [IQR 12, 16] years) with hypertension were included. Left ventricular hypertrophy was diagnosed in 39.5% of participants. Normal geometry was found in 47.1%, concentric remodeling (CR) in 13.4%, concentric hypertrophy (CH) in 15.1%, and eccentric hypertrophy (EH) in 24.4% of children. After adjustment for age, sex, and body mass index z-score, awake systolic blood pressure (BP) index (BPi) (OR 1.07, 95% CI: 1.001-1.14, P = 0.045), awake diastolic BPi (OR 1.04, 95% CI: 1.00-1.09, P = 0.048), awake systolic BP load (OR 1.02, 95% CI: 1.000-1.04, P = 0.047), and sleep systolic BP load (OR 1.02, 95% CI: 1.001-1.04, P = 0.03) were directly associated with CH. No ABPM parameters were significant predictors of EH. In conclusion, ABPM parameters were found to be independent predictors of cardiac geometry, specifically CH.
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Shilly et al. (2019) conducted an observational in primary hypertension (n=119). Ambulatory blood pressure parameters was evaluated on Concentric hypertrophy (CH) (OR 1.07, 95% CI 1.001-1.14, p=0.045). Higher awake systolic blood pressure index was independently associated with concentric hypertrophy in children and adolescents with primary hypertension (OR 1.07; 95% CI 1.001-1.14; P=0.045).
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