Why the study?
Does neonatal transplantation of PSC-derived cardiomyocytes induce maturation conducive to modeling adult-onset cardiomyopathy?
Population
Pluripotent stem cell-derived cardiomyocytes, including patient-derived cells for arrhythmogenic right…
Comparison
In vivo transplantation into neonatal rat hearts vs In vitro culture (dish)
Design
Preclinical
Follow-up
within a month
Authors
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Neonatal transplantation may enable adult-like PSC-CM maturation for cardiomyopathy modeling; hypothesis-generating and requires validation beyond rodents.
Does neonatal transplantation of PSC-derived cardiomyocytes induce maturation conducive to modeling adult-onset cardiomyopathy?
Transplanting PSC-derived cardiomyocytes into neonatal rat hearts overcomes the in vitro maturation arrest, enabling the modeling of adult-onset cardiomyopathies like ARVC.
Cho et al. (2017) studied this question.
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